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KMID : 0360220190600030276
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Journal of the Korean Ophthalmological Society
2019 Volume.60 No. 3 p.276 ~ p.279
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A Case of Clozapine-induced Corneal and Lenticular Pigmentation
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An Ji-Seon
Lee Young-Mi
Kwag Joo-Young
Hyun Joo
Choi Jin-Seok
Pak Kyu-Hong
Chung Sung-Kun
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Abstract
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Purpose: To report a case of corneal and lenticular pigmentation after prolonged clozapine therapy.
Case summary: A 56-year-old male visited our hospital with a progressive decline in vision that affected both eyes. He had a history of schizophrenia. He was being treated with 200 mg clozapine and 1 mg lorazepam daily, and had been treated with clozapine for 5 years. At the first visit, his best-corrected-visual acuity was 20/32 in both eyes. Slit lamp examination of the corneas showed bright, fine, grayish-brown deposits on the endothelium, and on dilation, bilateral central stellate opacity of the anterior portion of the lens capsule was revealed.
Conclusions: Clozapine may induce corneal and lenticular pigmentation and thus may lead to a decline in vision. Patients on long-term clozapine therapy should be considered for regular ophthalmic review.
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KEYWORD
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Clozapine, Corneal pigmentation, Lenticular pigmentation
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